ovarian cancer – TechConnect Briefs

Modular Nanoparticle Probes for Personalized in Vitro and in Vivo Imaging of Cancer Cell Populations

Nallathamby P.D., Cowden-Dahl K., Roeder R.K., University of Notre Dame, US

The high mortality and poor prognosis for women diagnosed with ovarian cancer is mainly due to late diagnosis. Improved detection of primary tumors and recurrence after chemotherapy is, therefore, crucial to reduce ovarian cancer mortality [...]

Modulation of Intracellular Ceramide using Polymeric Nanoparticles to Overcome Multidrug Resistance in Tumor Cells

van Vlerken L.E., Shenoy D., Duan Z., Seiden M., Mehta S., Amiji M.M., Northeastern University, US

This work describes the formulation of a nanoparticle drug delivery system to co-administer a chemotherapeutic, paclitaxel, and an MDR modulator, C6-ceramide, aimed at overcoming multidrug resistance (MDR) of solid tumors. MDR can arise through several [...]

Photo-Enhanced Luminescence in Bio-conjugated Quantum Dots for Ovarian Cancer Biomarkers

Dybiec M., Korsunska N.E., Zhukov P., Zhukov T., Ostapenko S., Sellers T., Zajac A., Zhukov P., Zhukov T., University of South Florida, US

Ovarian cancer is the most lethal gynecologic malignancy. This largely reflects the fact that approximately 75% of cases are detected at advanced stages of disease, when cure is unlikely. In contrast, 5-year survival for patients [...]