miRNA – TechConnect Briefs

miRNA Expression Analysis in HEp-2 Cells after Gold Nanorod Application

Montgomery A., Bawage S., Chaudhary A., Singh S.R., Vig K., Alabama State University, US

Gold Nanoparticles are popular because of their use in drug delivery and other biomedical applications. However, not much is known about their toxicity. The purpose of the present study was to evaluate the toxicity of [...]

Amplified On-Chip Fluorescent and Colorimetric Detection of DNA and RNA Hybridization by Surface-Initiated Enzymatic Polymerization

Tjong V., Yu H., Hucknall A., Chilkoti A., Duke University, US

We present a new on-chip, isothermal signal amplification technique for direct detection of unmodified DNA and RNA on microarrays using terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase that catalyzes the sequential addition of deoxynucleotides [...]

An OMICs Approach for Assessing the Safety of Single-Walled Carbon Nanotubes in Human Skin and Lung Cells

Cunningham M.J., Shah M., Lema C., Magnuson S., Falduto M., Balzano L., Resasco D., Houston Advanced Research Center, US

High-throughput OMICs biotechnologies combined with a systems biology approach were used to screen for the toxicity of nanomaterials. Profiling of the macromolecular interactions within human cells was done with mRNA and miRNA expression microarrays (genomics) [...]