dendrimer – TechConnect Briefs

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Fomina N., McFearin C., Sermsakdi M., Morachis J., Almutairi A., University of California at San Diego, US

We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. [...]

Novel Catalysis of Dendrimer: Efficient Nanocavity of Polyamine Dendrimer for Intramolecular Michael Reaction

Maeno Z., Mitsudome T., Mizugaki T., Jitsukawa K., Kaneda K., Osaka University, JP

The intramolecular Michael reaction of (E)-9-nitro-3-nonen-2-one was investigated using poly(propylene imine) dendrimers with alkyl chain on the periphery (Gx-C16, x = 3-5, x denotes the number of the generation). Gx-C16 showed higher catalytic activity than [...]

Controlled Synthesis of Subnano Pd Cluster Catalysts by Fine Tuning of Dendrimers

Mizugaki T., Kibata T., Maeno Z., Mitsudome T., Jitsukawa K., Kaneda K., Osaka University, JP

We recently succeeded in the fine control of the Pd cluster sizes in wide range using the fifth generation poly(propylene imine) (PPI) dendrimers. Preorganization of Pd ions within the PPI dendrimer with butanediamine core(G5-C4) and [...]

Pharmacokinetics and clearance properties of nano-sized particles and molecules as multi-modality imaging agents: Considerations and caveats

Kobayashi H., NCI/NIH, US

Nano-sized particles and molecules possess enormous potential as diagnostic imaging agents and hold promise for the development of multimodality agents with both imaging and therapeutic capabilities. Yet, some of the most promising nano-materials currently under [...]

POSS–Substituted Hyperbranched Polyester Blends with Thermoplastic Polyurethanes

Spoljaric S., Shanks R.A., RMIT University, AU

The aim of this research is to prepare and disperse in an elastomer a multi-branched form of POSS. Hyperbranched polymers (HBP) can be formed by grafting from a central core. POSS may be joined with [...]

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

Nanofabrication of Biomaterial, CNT and Organic Polymer Patterned Thinfilms using Piezoelectric Ink Jet Printing

Sumerel J.L., Deravi L.F., Wright D.W., Dimatix, Inc., US

In contrast to thermal ink jetting that uses heat to generate fluid drop ejection, MEMS-constructed piezoelectric ink jet printheads use a thin PZT slab bonded to a silicon diaphragm to generate acoustic energy that drives [...]

Labeling of Cells with Silver and Gold Host-Guest Nanocomposites

Balogh L.P., Lesniak W., Sinani V.A., Bielinska A.U., Sun K., Nair B.M., Waite E., Kariapper M.S.T., Khan M.K., Roswell Park Cancer Institute, US

Nanocomposites combine the properties of nano-sized inorganic guest atoms/molecules with their nanoscopic size polymer host. We have synthesized water-soluble, biocompatible, fluorescent, and stable nanocomposites with regulated surface charge and controlled size for cell labeling studies. [...]

Dendrimer Nanoparticles for Extending Biosensor Lifetime

Qian X., Tabacco M.B., Smiths Detection, US

Smiths Detection has been developing semi-selective optical biosensors for the direct airborne detection of the four primary classes of biological warfare agent: bacteria, bacterial spores, toxins and viruses. The sensors have good sensitivity and selectivity. [...]

Condensation of Therapeutic Oligodeoxynucleotides and Plasmid DNA with PPI Dendrimers and PPI-Modified Gold Nanoparticles

Chen A.M., Nair S.K., Thomas T.J., Thomas T.T., Thomas T.J., Thomas T.T., He H., Rutgers Unverisity, Newark, US

We demonstrated the formation of oligonucleotide nanoparticle in the presence of polypropylenimine dendrimers using total intensity light scattering as well as AFM and TEM. Confocal microscopic analysis showed that the nanoparticles formed with G4 and [...]