cell sorting – TechConnect Briefs

A Microsystem and Model for Continuous Immunomagnetic Cell Sorting

Furlani E.P., University at Buffalo (SUNY), US

We present a microsystem concept and mathematical model for the continuous sorting of magnetically labeled cells. The microsystem consists of two inlets, two partially connected microchannels, and two outlets. A soft-magnetic element is positioned beneath [...]

A Micromachined Sparse Cell Isolation Device: Application in Prenatal Diagnostics

Mohamed H., Turner J.N., Caggana M., Wadsworth Center, New York State Department of Health, US

The isolation of fetal cells from maternal circulation is the subject of intense research. Fetal cells can be isolated using several enrichment methods, however no technique to specifically isolate and use them for genetic diagnosis [...]

Circulating Tumor Cells: Capture with a Micromachined Device

Mohamed H., Murray M., Turner J.N., Caggana M., New York State Department of Health, US

The isolation and analysis of circulating tumor cells (CTCs) from blood is the subject of intense research. Tests to detect metastasis are available but progress is hampered by the lack of tumor-specific markers and predictable [...]

Three-Dimensional Single Step Flow Sheathing in Micro Cell Sorters

Goranovic G., Perch-Nielsen I., Larsen U.D., Wolff A., Kutter J., Telleman P., Bio/Chemical MicroSystems, DK

We present a novel microstructure that enables 3 dimensional hydrodynamic focusing of cells in a pressure driven micro cell sorter. This so-called "chimney" structure for single step coaxial sheathing was designed and optimized through simulation, [...]