biomolecule – TechConnect Briefs

Atomistic Simulations of Biomolecules at the Water‐Amorphous Silica Interface: Application to Peptides and DNA Oligomers

Shi B., Shin Y.K., Shin Y.K., Hassanali A., Singer S.J., Ohio State University, US

Realistic modeling of biomolecules near amorphous silica (“glass”), a material commonly used for biomedical device fabrication, is required for device design and evaluation. Our potential model, based on ab initio quantum chemical calculations, is designed [...]

Fabrication of size-tunable gold nanoparticles using plasmid DNA as a biomolecular reactor

Samson J., Piscopo I., Yampolsky A., Nahirney P., Parpas A., Toschi A., Drain C.M., Hunter College of CUNY, US

Plasmid DNA has proven to be a successful template/mold for the formation of metallic nanoparticles because it is readily available, inexpensive, and malleable i.e. it can exist in different topologies. Using different plasmid DNA species [...]

Fabrication of interdigitated nanogap devices for biomolecular detection

Park H.J., Chi Y.S., Ah C.S., Ha D.H., Choi I.S., Yun W.S., Korea Research Institute of Standards and Science (KRISS), KR

One of the most fascinating fields of nanodevice research is its application to the detection of biologically important entities such as DNAs, peptides, antigens, enzymes, viruses, and cells. Nanoelectronic devices adopted in this study are [...]

A Curved Panel Integration Technique for Molecular Surfaces

Bardhan J.P., Altman M.D., Lippow S.M., Tidor B., White J.K., Massachusetts Institute of Technology, US

A key step in computational drug design is the calculation of binding free energies between drug candidates and their target; one important component of these binding free energies is the van der Waals interactions that [...]