Imaging the Distribution of High Colloidal Stability Mesoporous Silica Nanoparticles (MSNs) with PET and MRI

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Biocompatible and high porosity mesoporous silica nanoparticles (MSNs) represent a significant advance in drug delivery applications, currently entering clinical validation. It will be necessary to track these drug vectors over time with medical imaging techniques. [...]

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

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We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]