Yakovlev S.G. – TechConnect Briefs

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Yakovlev S.G., Bonartsev A.P., Bonartseva G.A., Bagrov D.V., Efremov Yu.M., Boskhomdzhiev A.P., Filatova E.V., Ivanov P.V., Makhina T.K., Bonartseva G.A., A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, RU

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) [...]

Amorphous and semicrystalline phases in ultrathin films of poly(3-hydroxybutirate)

Bagrov D.V., Bonartsev A.P., Bonartseva G.A., Zhuikov V.A., Boskhomdzhiev A.P., Myshkina V.L., Makhina T.K., Zharkova I.I., Yakovlev S.G., Voinova V.V., Ivanov P.V., Bonartseva G.A., Shaitan K.V., Lomonosov Moscow State University, Faculty of Biology, RU

Poly(3-hydroxybutirate) (PHB) is a bacterial polyester, which shows a high potential as a material for biotechnology and medicine, including drug delivery and production of biodegradable implants. Being a semicrystalline polymer, PHB is able to form [...]