Verrall R. – TechConnect Briefs

Dicationic gemini surfactant gene delivery complexes contain cubic-lamellar mixed polymorphic phase

Foldvari M., Wettig S., Badea I., Verrall R., Bagonluri M., University of Saskatchewan, CA

The characterization of structural properties of novel dicationic (gemini) surfactant-based DNA complexes as micro/nano-scale self-assembling delivery systems for cutaneous gene therapy is described and discussed as related to measured transfection efficiencies. Previous small-angle x-ray scattering [...]

Structural Characterization of Novel Micro- And Nano-Scale Non-Viral DNA Delivery Systems for Cutaneous Gene Therapy

Foldvari M., Badea I., Wettig S., Verrall R., Bagonluri M., University of Saskatchewan, CA

Our main goal is to develop micro/nano-scale self-assembling delivery vehicles for cutaneous gene therapy. The objective of this study was to characterize the structural and physicochemical properties of novel dicationic lipid-based DNA complexes by atomic [...]