Tirelli N. – TechConnect Briefs

Characterisation of THP-1 macrophages as an in vitro model for CD44-targeted therapies

M. Rios de la Rosa J., Tirella A., Gennari A., Tirelli N., University of Manchester, UK

CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]