Tan E. – TechConnect Briefs

Electronic DNA detection on semiconductor surfaces

Han Y., Tan E., Candebat D., Bandyopadhyay K., Niemz A., Keck Graduation Institute, US

Electronic biosensors offer a viable alternative to optical biosensors for the rapid, specific, and sensitive detection of DNA. We are utilizing an electrolyte-oxide-semiconductor (EOS) biosensor system on a SiO2/Si surface for impedimetric detection of DNA. [...]

Rapid Isothermal Amplification and Multiplexed Surface Detection of Short DNA Sequences

Tan E., Han Y., Kniazeva E., Buechel M., Erwin B., Niemz A., Keck Graduate Institute, US

We have coupled a novel isothermal amplification method for short oligonucleotides (EXPAR) with solution and surface-based detection involving DNA-functionalized gold nanospheres. In these assays, a trigger oligonucleotide is exponentially amplified and converted to a reporter [...]