Stuartb M. – TechConnect Briefs

Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to [...]

Structural Elucidation of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy in air and water

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

Doxil is a clinically used, FDA-approved liposomal product against cancer. Structural elucidation of liposomal doxorubicin by cryogenic-transmission electron microscopy (cryo-EM) showed that doxorubicin (Dox)form crystal-like structures inside liposomes. Since 1992, cryo-EM has been the only [...]