Sen T. – TechConnect Briefs

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Patil-Sen Y., Eizadi Sharifabad M., Mercer T., Bond G., Patil-Sen Y., Sen T., University of Central Lancashire, UK

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug [...]

Enantioselective desymmetrization of meso-cyclopent-2-en-1,4-diacetate to 4-(R)-hydroxycyclopent-2-en-1-(S)-acetate using enzyme immobilized superparamagnetic nanocomposites

Eizadi Sharifabad M., Sen T., University of Central Lancashire, UK

Enzymes are well established as catalysts for various bio-transformations. However, it is difficult to remove the expensive enzymes from the reaction mixtures. Hence, immobilization of enzymes on solid support is a very important step for [...]

Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery

Sharifabad M.E., Mercer T., Sen T., University of Central Lancashire, UK

Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell [...]

Novel Hierarchically Ordered Porous Vanado-Silicate Nanocomposites for the Application in Industrial Catalysis

Howard M., Whittle J., Zhang F., Zhao D., Sen T., University of Central Lancashire, UK

A novel hierarchically ordered porous vanado-silicate nanocompsoites were fabricated with isolated vanadium species with well dispersed state in the porous martrix for the oxidation of bulkier organic molecules i.e cyclooctene for the selective production of [...]

Magnetoliposomes: Stability of Magnetic Nanoparticles in Suspension for drug delivery

Sen T., Sheppard S.J., Mercer T., Elhissi A., University of Central Lancashire, UK

A simple and rapid one pot method of synthesis of magneto-liposome has been reported. The nanoparticles exhibited exceptional stability in suspension. Magnetoliposomes were efficient for DNA binding/elution and drug loading.

Novel Nanocomposites: Hierarchically Ordered Porous Silica for the Immobilisation of Enzyme as Bio-catalyst

Sen T., Sen Y., Sen T., Sen Y., University of Central Lancashire, UK

A novel nanocomposites has been synthesised and used as a support for immobilisation of lipase for the hydrolysis of ester. The synthesis of nanocomposites has been patented and published in the high impact factor journals [...]

A Generalised Approach for the Surface Engineering of Nanoparticles in Suspension for Highly Efficient Hybrid Capture of Bio-molecules

Sen T., Bruceb I.J., University of Central Lancashire, UK

A generalised method of surface engineering of nanoparticles in suspension has been reported using a novel strategy “Tri-phasic reverse Emulsion” or TPRE. In this method, the surface functionalisation of nanopaticles can be controlled by controlling [...]