Perez J.M. – TechConnect Briefs

From Rational Design to Probe Optimization: the Role of Nanoparticle Valency in Single Cancer Cell Detection in Blood via Magnetic Relaxation

Kaittanis C., Santra S., Perez J.M., University of Central Florida, US

The conjugation of targeting ligands to iron oxide nanoparticles has achieved the development of specific assays for the detection of biomedical targets through magnetic relaxation. However, limited studies investigated how the nanoparticle valency modulates the [...]

Identification of Molecular-Mimicry-Based Ligands for Cholera Diagnostics using Magnetic Relaxation

Santiesteban O.J., Kaittanis C., Banerjee T., Santra S., Teter K., Perez J.M., University of Central Florida, US

Magnetic nanosensors (MRnS) offer multiple benefits that can be used to design sensitive and robust diagnostic tools. High sensitivity, stability, and ease of surface modification make this approach a strong contender against the more commonly [...]

Identification of bacterial drug resistance in blood

Kaittanis C., Nath S., Perez J.M., University of Central Florida, US

Development of antibiotic resistance by microorganisms has been on the rise in recent years. Therefore, identifying drug resistant strains and effective antibiotic agents is critical. Traditional microbiological methods assess antimicrobial susceptibility within 24 to 48 [...]

Intrinsic oxidase activity of cerium oxide nanoparticles facilitate the detection of cancer biomarkers and cancer cells

Perez J.M., Asati A., Santra S., Kaittanis C., Nath S., University of Central Florida, US

Nanomaterials exhibit unique size-dependent physical properties. Thus, identifying novel properties of these materials at the nanoscale, and their applications in energy, catalysis and medicine, among others, is an area of current and intense research. Cerium [...]

Identification of bacterial susceptibility to antibiotics using gold nanoparticles

Perez J.M., Kaittanis C., Nath S., University of Central Florida, US

Inexpensive and rapid methods for detecting bacterial infections and their corresponding susceptibility to antibiotics are desperately needed. The determination of which antibiotic to use and its administration at dosages that will effectively suppress bacterial growth [...]

Synthesis of Dextran-Coated Nanoceria with pH-dependent Antioxidant Properties

Perez J.M., Asati A., Nath S., Kaittanis C., University of Central Florida, US

Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]

An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes

Perez J.M., Fries D.P., Hickman J.J., University of Central Florida, US

The use of nanoparticles and NMR detection technologies has lead to significant improvements in sensitivity. Nanoparticles have many useful optical and electronic properties derived from their small size. When coupled to affinity ligands, these materials [...]

An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes

Perez J.M., Fries D.P., Hickman J.J., University of Central Florida, US

The use of nanoparticles and NMR detection technologies has lead to significant improvements in sensitivity. Nanoparticles have many useful optical and electronic properties derived from their small size. When coupled to affinity ligands, these materials [...]