Sustained-release liquisolid compacts of lumenfantrine-artemether as alternate-dayregimen for malaria treatment to improve patient compliance
Nnamani P.O., Ugwu A.A., Ibezim E.C., Kenechukwu F.C., Ogbonna J.D.N., Obitte N.C., Chime S.A., Attama A.A., University of Nigeria, Nsukka, NG
Lumenfantrine-SLN (LUM, 0.2, 0.5, 0.8 and 1%w/w)formulated with Precirol-Transcutol (PT) and Tallow fat-Transcutol (TT) at 3:1 contained surfactants (Poloxamer 188, Polysorbate 80 and Solutol HS). PS, ZP, PDI,morphology, EE, interaction study and in vitro drug [...]