Controlled Intracellular Release of Camptothecin by Glutathione-Driven Mechanism
Botella P., Muniesa C., Vicente V., Fabregat K., Cabrera A., Instituto de Tecnologia Quimica (UPV-CSIC), ES
Direct coupling of camptothecin (CPT) to nanoparticles is circumvented by the reduced therapeutic activity of its structure-modified derivatives. To negotiate this problem, we have developed a novel CPT nanoplatform based in a mercapto-functionalized silica hybrid [...]