Mitragotri S. – TechConnect Briefs

Understanding the Cytoplasmic Transport of Synthetic Gene Vectors

Pangarkar C., Dinh A.T., Mitragotri S., university of california, santa barbara, US

We use fluorescence video microscopy and single particle tracking to elucidate some of the fundamental mechanisms involved in intracellular trafficking of non-viral gene vectors. Transport of polymer-DNA complex, which are internalized via endocytosis, is almost [...]

Simulation of Viral Gene Delivery

Dinh A.T., Mitragotri S., Theofanous T., university of california, santa barbara, US

Here we develop an integrative computational framework to model biophysical processes involved in viral gene delivery. The model uses reaction-diffusion-advection equations that describe intracellular trafficking in combination with kinetic equations that describe transcription and translation [...]