Leung S.W. – Page 4 – TechConnect Briefs

Chitosan Film/Membrane as a Surface to Alter Brain Glioma Growth and Migration

Gao W.J., Wang Y.-H., Gu H.-Y., Jandhyam S., Dukhande V.V., Lai J.C.K., Lai M.B., Leung S.W., Bhushan A., Lai J.C.K., Lai M.B., Idaho State University, US

A hydrophilic polysaccharide derived from chitin, chitosan has gained increasing popularity in biomedical applications such as tissue engineering, wound dressing, and drug delivery because of its presumed biocompatibility. These applications were founded on chemical similarities [...]

Performance Comparisons of Nanoparticle Modified Sensor Electrodes for the Detection of Nitrite and Peroxide

Lai J.C.K., Wang Y., Gao W., Gu H., Leung S.W., Idaho State University, US

For the third generation of biosensor that electrode is coupled directly with enzymes, the response time for detection is rapid but stability of the measurements and the coupled enzymes is a concern. In our research [...]

Characterization and Applications of Modified Gold Electrode Sensor with Nanoparticles

Leung S.W., Wang Y., Gu H., Lai J.C.K., Idaho State University, US

In the recent development of biosensor, response time of the sensor is drastically improved by using direct coupling of enzymes onto the surface of electrode. The drawback of the direct coupling of enzymes is denature [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]

Characterization of DNA Transport through a Semipermeable Membrane with the Effect of Surfactants

Leung S.W., Bartolin S., Daniels C.K., Lai J.C.K., Idaho State University, US

In current advances of biotechnology, various models of introduction of DNA into cells to alter their gene expression have important biomedical and bioengineering applications. However, the molecular mechanisms underlying how DNA’s cross cell and nuclear [...]

A Non-Contact Culture Model for Investigating Cell Signaling and Nanotoxicity

Gao W.J., Dukhande V.V., Jandhyam S., Wang Y.-H., Gu H.-Y., Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Leung S.W., Idaho State University, US

There is general agreement that in vitro cell model systems offer many advantages over in vivo model systems in elucidation of cell signaling and other mechanisms underlying a toxicant’s effect. While the 3-D cell models [...]

A Co-Culture Model for Nanotoxicity and Tissue Engineering Studies

Wang Y.-H., Jandhyam S., Dukhande V.V., Gao W.J., Gu H.-Y., Lai J.C.K., Lai M.B., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

Cell model systems in vitro play vital roles in recent advances in toxicological and tissue engineering research. They are particularly versatile in facilitating signaling and related mechanistic studies. Although the 3-D cell models better simulate [...]

Differential Cytotoxicity of Metallic Oxide Nanoparticles in Mammalian Cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Nanomaterials have been increasingly used in industrial applications (e.g., drug delivery, additives to drugs and cosmetics). Because of their wide use, occupational exposure to nanomaterials and nanoparticles may pose as health risks. Recent studies have [...]

Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types

Jandhyam S., Lai J.C.K., Lai M.B., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Applications of nanomaterials (e.g., silicon dioxide (SiO2) nanoparticles) are ubiquitous. Thus, environmental and occupational exposure to these nanoparticles could pose potential health risk. SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are [...]

Silicon Dioxide Nanoparticles Can Exert Cytotoxic Effects on Neural Cells

Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Edgley K.L., Bhushan A., Dukhande V., Daniels C.K., Leung S.W., Idaho State University, US

The health risk and cytotoxic effects of nanoparticles are almost unknown. Consequently, we have launched an interdisciplinary research program to systematically investigate the toxicity of nanoparticles. An initial observation prompted us to hypothesize that SiO2 [...]