Dex40-GTMAC3, modified dextran as a novel heparin antagonist
Kalaska B., Kaminski K., Sokolowska E., Czaplicki D., Kujdowicz M., Stalinska K., Szczubialka K., Bereta J., Pawlak D., Nowakowska M., Mogielnicki A., Medical University of Bialystok, PL
Protamine is the only registered antidote preventing bleeding of patients treated with unfractionated heparin (UFH). However protamine may induce anaphylactic shock or serious hypotension. We aimed to develop an alternative fully synthetic UFH antidote as [...]