Kostarelos K. – TechConnect Briefs

Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to [...]

Structural Elucidation of Doxorubicin-Loaded Liposomes by Atomic Force Microscopy in air and water

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

Doxil is a clinically used, FDA-approved liposomal product against cancer. Structural elucidation of liposomal doxorubicin by cryogenic-transmission electron microscopy (cryo-EM) showed that doxorubicin (Dox)form crystal-like structures inside liposomes. Since 1992, cryo-EM has been the only [...]

Improved Tissue Distribution, Renal Clearance and Toxicity Profile of Functionalised Carbon Nanotubes

Lacerda L., Prato M., Bianco A., Kostarelos K., The School of Pharmacy, University of London, UK

Carbon nanotube (CNT) development for biomedical applications is in the nascent stages, however is thought to lead to novel types of diagnostic, therapeutic and regenerative nanomedicines. The construction of CNT-based delivery systems able to traffick [...]

Mechanisms of Cellular Interaction, Binding and Internalization of Functionalized Carbon Nanotubes

Lacerda L., Prato M., Bianco A., Kostarelos K., The School of Pharmacy, University of London, UK

The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest. Carbon nanotubes (CNT) are thought to lead to novel types of nanomedicines. In our [...]

Multiwalled Carbon Nanotube-Doxorubicin Supramolecular Complexes for Cancer Therapeutics

Ali-Boucetta H., Al-Jamal K.T., Kostarelos K., The School of Pharmacy, University of London, UK

The field of drug delivery is being revolutionised by the discovery of novel nanomaterials such as carbon nanotubes (CNTs) capable of traversing the plasma membrane and promoting the cellular uptake of small molecules and macromolecules [...]