Reviving natural product and drug discovery pipelines with fungal artificial chromosome (FAC) technology
Clevenger K., Bok J.W., Ye R., Miley G., Velk T., Chen C., Yang K.H., Gao P., Lamprecht M., Thomas P., Islam M.D., Keller N., Kelleher N., Wu C., Intact Genomics, Inc., US
We have developed the fungal artificial chromosome [FAC, or autonomously replicating E. coli- fungal shuttle bacterial artificial chromosome (BAC)] vector and system. The FAC technology enables unbiased capturing of 263 full-length large secondary metabolite (SM) [...]