Kasturirangan V. – TechConnect Briefs

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

In Vitro Toxicity Study of Gold and Tin Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Kariapper M.S.T., Kasturirangan V., Nair B., Lesniak W., Balogh L.P., Roswell Park Cancer Institute, US

Composite nanodevices, with PAMAM dendrimer and inorganic metal components, are currently being developed as an exciting nanoplatform for several types of molecularly targeted cancer therapy and imaging. Due to its unique chemical structure of dendrimers, [...]

Inflammation and Cellular Toxicity Study of PAMAM Dendrimer Nanoparticles in Primary Isolated Human Lung Cells

Khan M.K., Kariapper M.S.T., Kasturirangan V., Lesniak W., Sharma M., Baumann H., Balogh L.P., Translational Research Scientist, US

Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]