Chen E.T. – Page 2 – TechConnect Briefs

Nanobiomimetic Memristor/Memcapacitor Devices Used for Direct and Reagent-less Detection of Sub pM Acetyl Coenzyme A in Milks

Duh S-H, Thornton J., Kissinger P.T., Chen E.T., advanced biomimetic sensnors, inc, US

Acetyl co-enzyme A (AcCoA) is a leading substrate in a large variety of enzyme-catalyzed reactions, such as for choline acetyltransferase and acetylcholinesterase. They are critical to energy production, metabolism, memory, cell proliferation and early childhood [...]

Acetylcholine Repairs the Amyloid-beta Damage on Brain Circuitry and Memory Loss From a “Mutated Biomimetic Acetylcholinesterase” Neuronal Memcapacitor During Slow-Wave Sleeping

Thornton J., Mulchi Jr. C., Kissinger P.T., Chen E.T., Advanced Biomimetic Sensors, Inc., US

Amyloid-beta (A) plaque accumulation in the brain has been recognized to be associated with Alzheimer’s. Using artificial neuronal devices under controlled conditions, step-by-steps mimicking the A damages to neuronal circuitry is desirable, because of convenience [...]

Nanobiomimetic Memcapacitor Memory Devices Identify Circadian Rhythm Dysfunction and Predict Early Signs of “Epilepsy” Using Reentrant Energy-Sensory Images

Chen E.T., Thornton J., Mulchi Jr. C., Advanced Biomimetic Sensors, Inc., US

Circadian Rhythm (CRR) dysfunction of Alzheimer’s has been recognized as an early sign in correlation with -Amyloid (A) damage late happened in the brain. We report a nanostructured memcapacitor memory device for detecting an energy [...]

A Nanobiomimetic Neuronal Memcapacitor Serves as a Voltage Sensor and an Amperometry Sensor for Reagent-less Direct Detection of Sub pM Soluble Amyloid-beta

Duh S-H, Thornton J., Kissinger P.T., Chen E.T., Advanced Biomimetic Sensors, Inc., US

Amyloid-beta (A) plaque accumulation in the brain has been recognized to be associated with Alzheimer’s and dementia. Challenges of quantitation of Ab are the instability of soluble Ab1-42 and the protein interference plus the time [...]

Nanostructured Acetylcholinesterase (ACHE) Memristor/Memcapacitor Mimicks Brachyhypopomus Electric Fish’s Signal-Cloaking Behavior

Chen E.T., Thornton J., Advanced Biomimetic Sensors, Inc., US

The Brachyhypopomus Electric (BHE) fish is known for its signal-cloaking behavior that allows it to avoid predators by shifting its electroreceptive pulses from low frequency to less detectable high-frequency through a phase-delay “head-tail” Electric Organ [...]

Nanostructured Acetylcholinesterase (ACHE) Memristor/Memcapacitor Mimicks Brachyhypopomus Electric Fish’s Signal-Cloaking Behavior

Chen E.T., Thornton J., Advanced Biomimetic Sensors, Inc., US

The Brachyhypopomus Electric (BHE) fish is known for its signal-cloaking behavior that allows it to avoid predators by shifting its electroreceptive pulses from low frequency to less detectable high-frequency through a phase-delay “head-tail” Electric Organ [...]

Nanostructured Biomimetic Memristor Sensors Used for Therapeutic Monitoring of the Brain Cancer

Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Current technology is not available to provide a portable, simple and accurate real-time monitoring and treatment of cancers simultaneously in an early stage at a clinical setting. Challenges for developing such a tool, include the [...]

Nanostructured Memristor Sensor Mimics Acetylcholinesterase (ACHE) Active Sites in the Gorge for fM Detection of Acetylcholine

Chen E.T., Thornton J., Ngatchouand C., Duh S-H, Advanced Biomimetic Sensors, Inc., US

Many diseases including cancer, diabetes, brain injury, epilepsy, Parkinson’s, autism and Alzheimer’s involve the up regulation of acetylcholinesterase (ACHE) inappropriately signaling of cholinergic synapse for an excess production of the neurotransmitter acetylcholine (ACH). Challenges for [...]

Flexible and Turnable Biomimetic Pyruvate Dehydrogenase Complex (PDC) Supercapacitors

Thornton J., Christelle C., Chen E.T., Advanced Biomimetic Sensors, Inc., US

Flexible supercapacitors are challenged by low energy density and short discharge time. We report a new type of biomimetic pyruvate dehydrogenase complex (BIMPDC) supercapacitors having the self-assembling membrane (SAM) offer orders of magnitude higher in [...]

Study the Correlations Between Direct Electron Transfer Rate Constants in Four Types of Nanobiomimetic Sensors and the Ability to Kill Cancer Cells from Anti-Cancer Candidate Compounds

Chen E.T., Thornton J., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

We report a new approach to study Direct Electron Transfer (DET) rate constants between an electrode surface and an active biomimetic receptor using four types of gold nanobiomimetic sensors. The goal is to find the [...]