The binding site interactions between 7-chloro-tetracycline and the Tet Repressor
de Bruin P.H.S., Flores M.Z.S., Caetano E.W.S., Cavada B.S., Freire V.N., Universidade Federal do Ceará, BR
Tetracyclines are a class of broad spectrum antibiotics whose use has been limited by the emergence of bacterial resistance. The most common mechanism of resistance is regulated by the repressor protein, TetR. The structure of [...]