Casey B.J. – TechConnect Briefs

Physico-chemical Characterization of Extracts of Silver Nanoparticle Containing Medical Devices

Casey B.J., Jayanti P., Sussman E.M., Dair B.J., U.S. Food and Drug Administration, US

The main goal of this research was to gain a better understanding of the extraction profile of medical devices containing silver nanoparticles. Multiple silver nanoparticle containing medical devices were incubated in various extract solutions (water, [...]

Understanding the Biological Impact of Nanoengineered Surfaces

Casey B.J., Kumar G., Petrochenko P., Skoog S.A., Narayan R.J., Goering P.L., Dair B.J., U.S. Food and Drug Administration, US

There is a growing trend in the medical device industry to manipulate the surface topography of a device with nanoscale features in order to promote advantageous biological responses such as better tissue integration and/or faster [...]

Titanium Dioxide Nanoparticles Interaction, Uptake and Genotoxicty in Salmonella typhimurium Bacteria

Casey B.J., Butler K.S., Elespuru R.K., Dair B.J., U.S. Food and Drug Administration, US

Due to their unique properties the use of nanoparticles (NPs) in consumer products is increasing rapidly. The expanding prevalence of NPs make it critical to understand the associated risk to both the public health along [...]

Understanding the Biological Impact of Nanoengineered Surfaces

Casey B.J., Kumar G., Petrochenko P., Skoog S.A., Narayan R.J., Goering P.L., Dair B.J., U.S. Food and Drug Administration, US

There is a growing trend in the medical device industry to manipulate the surface topography of a device with nanoscale features in order to promote advantageous biological responses such as better tissue integration and/or faster [...]

Understanding How Nanopatterning Affects Protein Deposition

Casey B.J., Silverstein J.S., Kofinas P., Dair B.J., U.S. Food and Drug Administration, US

This work focuses on understanding the effects that nanotopology has on protein adsorption. Functionalized block copolymers were synthesized and processed to produced highly ordered, nanopattered films. Experiments utilizing a quart crystal microbalance were completed to [...]

Assessing the Antimicrobial Activity of Silver Nanoparticles Leached from Medical Devices

Casey B.J., Dair B.J., U.S. Food and Drug Administration, US

This work focuses on characterization the leachables released from substrates, e.g. medical devices, containing silver nanoparticles. Furthermore, antimicrobial experiments were conducted to determine how the structure of a silver nanoparticle impact antimicrobial activity. Proper characterization [...]