Cabrera A. – TechConnect Briefs

In Vitro Delivery of Docetaxel to Cancer Cells by Hybrid PLGA@Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

Botella P., Quesada M., Vicente V., Cabrera A., Fabregat K., Instituto de Tecnologia Quimica (UPV-CSIC), ES

We have developed a novel hybrid material based in spherical PLGA nanoparticles containing hydrophobic molecules which have been covered by a thin layer (6-10 nm) of a redox-responsive amorphous organosilica shell. The outer layer incorporates [...]

Controlled Intracellular Release of Camptothecin by Glutathione-Driven Mechanism

Botella P., Muniesa C., Vicente V., Fabregat K., Cabrera A., Instituto de Tecnologia Quimica (UPV-CSIC), ES

Direct coupling of camptothecin (CPT) to nanoparticles is circumvented by the reduced therapeutic activity of its structure-modified derivatives. To negotiate this problem, we have developed a novel CPT nanoplatform based in a mercapto-functionalized silica hybrid [...]