Amiji M.M. – TechConnect Briefs

Use of PBMC Partitioning to Predict RES-Uptake of a Nanoemulsion in a Colon Cancer Xenograft

Devalapally H., Clogston J.D., Amiji M.M., McNeil S., Stern S.T., SAIC-Frederick, National Cancer Institute at Frederick, US

Nanotechnology platforms have emerged as versatile carrier systems for delivery of active molecules to tumors. Nanoparticle-based formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. These carrier systems often encounter rapid [...]

Formulation Optimization for the Nanoparticles-in-Microsphere Hybrid Oral Delivery Systems Using Factorial Design

Bhavsar M.D., Tiwari S.B., Amiji M.M., Northeastern University, US

The objective of the present study was to optimize the processing parameters for nanoparticles-in-microsphere hybrid system for oral delivery (NiMOS) and to mathematically relate the process parameters with the selected attribute (particle size) of the [...]

Nanotechnology for Drug Delivery: An Overview

Amiji M.M., Northeastern University, US

Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling [...]

Characterization and In Vivo Biodistribution Studies with Poly(Ethylene Glycol)-Modified Thiolated Gelatin Nanoparticles

Kommareddy S., Amiji M.M., Northeastern University, US

Objective: The objective of the current study was to synthesize and modify thiolated gelatin nanoparticles with PEG chains, characterize, and evaluate their long circulating and tumor targeting potentials in vivo in a human breast cancer [...]

Modulation of Intracellular Ceramide using Polymeric Nanoparticles to Overcome Multidrug Resistance in Tumor Cells

van Vlerken L.E., Shenoy D., Duan Z., Seiden M., Mehta S., Amiji M.M., Northeastern University, US

This work describes the formulation of a nanoparticle drug delivery system to co-administer a chemotherapeutic, paclitaxel, and an MDR modulator, C6-ceramide, aimed at overcoming multidrug resistance (MDR) of solid tumors. MDR can arise through several [...]

Nanoemulsion Formulations for Improved Oral Delivery of Poorly Soluble Drugs

Tiwari S.B., Shenoy D.B., Amiji M.M., Norheastern University, US

Purpose: To develop nanoemulsion formulations to enhance oral bioavailability of hydrophobic drugs. Paclitaxel was selected as a model hydrophobic drug. Methods: The oil-in-water (o/w) nanoemulsions were made with pine nut oil as the internal oil [...]