Electrochemical Detection of Single-Nucleotide Mismatches: Application of M-DNA
Abu-Irhayem E., Long Y-T., Sutherland T., Li C-Z, Kraatz H-B, Lee J.S., University of Saskatchewan, CA
The detection of a single-nucleotide mismatch in a 20 base pair duplex DNA, using Electrochemical Impedance Spectroscopy, is presented. Mismatched DNA monolayers on Au electrodes were studied as normal duplex DNA (B-DNA) and after conversion [...]