University of Zurich – TechConnect Briefs

Understanding the formation and adsorption of 2-dimensional and 3-dimensional protein aggregates on a solid surface

Rabe M., Verdes D., Seeger S., University of Zurich, CH

We have comprehensively investigated the structure of protein assemblies that form spontaneously upon protein adsorption on solid interfaces using a surface sensitive fluorescence imaging technique. It was found that proteins usually do not cover surfaces [...]

Parallel two channel near and far field fluorescence microscopy

Verdes D., Rabe M., Seeger S., University of Zurich, CH

We report a new two channel fluorescence microscopy technique for surface-generated fluorescence. The realized fluorescence microscope allows high resolution imaging of aqueous samples. The core element of the instrument is a parabolic mirror objective that [...]

Specific and Non-specific adsorption of Proteins on Solid Interfaces

Rabe M., Zimmermann J., Verdes D., Seeger S., University of Zurich, CH

We present a comprehensive mechanistic study of the non-specific adsorption of β-Lactoglobulin on a solid interface by comparing the adsorption kinetics of this protein to theoretical predictions of reported models. Important experimental observations were increasing [...]