Rush Medical College – TechConnect Briefs

Structure-function study of Porins

Chen D.P., Tang J., Eisenberg R.S., Rush Medical College, US

Single channel current-voltage (IV) relations were measured from proteins that form channels across the outer membranes of Gram-negative bacteria-porins and their mutants in solutions of KCl. The wild-type porins and some of their specific mutants [...]

Three-Dimensional Continuum Simulation of Biological Ion Channels

van der Straaten T.A., Tang J., Eisenberg R.S., Ravaioli U., Aluru N., Rush Medical College, US

We present a self-consistent continuum 3-D simulation of ion permeation through the ompF porin channel, a protein found in the membrane of the e-coli bacterium. The model is based on the simultaneous solution of Poisson's [...]