Pace University – TechConnect Briefs

Technological Challenges and Potential Advantages of Lipobeads as Drug Delivery Systems

Kazakov S., Pace University, US

Both polymeric and liposomal drug delivery systems tend to develop in the direction of increasing complexity, i.e. in accord with our understanding of the complex biological mechanisms prevailing in situ. To this point, one can [...]

Electrochemical Mechanics of Nanometer-Scaled Structural Layers of Bacterial Spores

Kazakov S.V., Pace University, US

The early events in the nutrient and non-nutrient germination of Bacillus subtilis spores are considered in combination with the properties of nanometer-scaled spore structural layers. All structural, not metabolically mediated, transformations at the early steps [...]

Polymer Network on Optical Fiber Core

Kazakov S.V., Pace University, US

The ultimate goal of the research is to fabricate a cylindrical polymer network (hydrogel) on the side-surface (not the distal end) of an optical fiber core and characterize spectroscopically its swelling/de-swelling ability in response to [...]

Proton Uptake by Dormant Bacterial Spores

Kazakov S.V., Pace University, US

A dormant bacterial spore is regarded as a natural ionic reservoir, i.e. a system capable of changing the external pH or ionic strength by accumulating or releasing ions. In this work, we introduce a method [...]

Protons’ binding within nanometer scaled compartments of natural ionic reservoirs: Bacillus subtilis spores

Kazakov S., Bonvouloir E., Gazaryan I., Pace University, US

Dormant spores of bacteria of Bacillus genus are intriguing micrometer-scaled objects for a physico-chemical study. The most paradoxical feature of dormant spores is that, being metabolically inactive and resistant to environmental insults, they actually monitor [...]

Lipobeads as Drug Delivery Sysytems

Kazakov S.V., Levon K.M., Pace University, US

Nanoparticles have been extensively studied as drug delivery systems. In this presentation, we focus on a relatively new type of nanoparticles – lipobeads – a liposome-hydrogel assembly as a novel drug delivery system. Lipobeads are [...]