P.A.Hertzen Moscow Research Oncological Institute (MROI)

Evaluation of Tools for Nanoparticles-modulated Hyperthermia by Atomic Force Microscopy

Reshetov I.V., Chissov V.I., Sukharev S.S., Matorin O.V., Korizky A.V., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Some of the properties of the medicinal forms and tools, supposed to be used as hyperthermia modulators, can be evaluated by the atomic force microscopy (AFM): sizes and concentration of nanoparticles, their capability for the [...]

Hybrid Nanoparticles Targeted by Antitumor Antibodies and Emitting Alpha-particles

Resheto I.V., Deev S.M., Chuvilin D.Y., Panchenko V.Y., Sukharev S.S., Streltsova E.A., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We describe a new therapeutic nanoparticle’s design, which consists of three parts: targeting, effecter and linker. Targeting part: an anti-HER2/neu mini-antibody-barnase fusion protein (4D5 scFv-barnase-His5). The anti-HER2/neu mini-antibody could be used to deliver barnase to [...]

Atomic Force Microscopy as a Tool for Research in Oncocytology

Reshetov I.V., Chissov V.I., Volchenco N.N., Sukharev S.S., Slavnova E.N., Ivanov Yu.S., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

Most of investigations have studied specimens prepared by complex techniques which are unusual for hospitals. In present paper Scanning Probe Microscopy (SPM) has been used for searching signs of malignancy in specimens prepared identically to [...]

Diffusion of Nanoparticles through the Tissues in Experiment

Reshetov I.V., Frank G.A., Sukharev S.S., Efremov G.D., Danileico Yu.C., Timoshenko V.Yu., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU

We have created nanocrystals of silicon with sizes in the greatest measurement in the average 50 nm (from 4 to 100 nm), and nanocrystals of the oxide of aluminum with the adsorbed molecules of phthalocyanines, [...]