Nanjing Medical University – TechConnect Briefs

Paclitaxel-functionalized aspragalan-calcium phosphate nanoparticles

He Q., Zhang X.Z., Yaun W.M., Zhau D.M., Fang Z.Q., Gang X.H., Nanjing Medical University, CN

Paclitaxel (PTX) is an important anticancer agent. Its aqueous solubility is very low; hence the available formulation of PTX for clinical use consists of Cremophor EL, which has been associated with several hypersensitivity reactions. In [...]

Synthesis and Biopharmaceutical Characterisation of a New Poly hydroxyethyl

Qi X-H, Lin W., He Q., Guan X-H, Nanjing Medical University, CN

A promising approach to improve drug delivery is to modify a polymeric backbone structure by means of copolymerization. Such obtained macromolecular prodrugs (polymer–drug conjugates) may offer many advantages compared to other drug delivery systems: increased [...]