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HomeAffiliationsMassachusetts Institute of Technology

Affiliations: Massachusetts Institute of Technology

Destruction of Organophosphate Agents by Recyclable Catalytic Magnetic Nanoparticles

Bromberg L., Hatton T.A., Massachusetts Institute of Technology, US
Organophosphorus pesticides and warfare agents are not readily hydrolyzed in aqueous media without applying extremes of pH, heat, or bleach. We show that suspensions of magnetite (Fe3O4) nanoparticles modified with a common antidote, 2-pralidoxime (PAM), [...]

Simulation on biological cell transport in the microfluidic devices

Kim M.C., Wang Z.H., Lam R.H.W., Thorsen T., Massachusetts Institute of Technology, US
We have developed a Bio-Particle (BP) simulation technique for the general particle movement in Lab-On-A-Chip devices. This has also been validated with experiments on biological cells (3T3 cell; diameter 10 μm). The cell motion under [...]

A Microfluidic Array with Micro Cell Sieves for Cell Cytotoxicity Screening

Wang Z.H., Kim M.C., Marquez M., Thorsen T., Massachusetts Institute of Technology, US
There is currently great interest in cell arrays for cell-based studies to improve experimental throughput. Microfluidics is an inherently scalable technology, offering an exciting new alternative to fabricate cell arrays for cell studies in a [...]

Nano Neuro Knitting: using nanotechnology to repair the brain

Ellis-Behnke R.G., Liang Y-X, You S-W, Tay D.K.C., Zhang S., So K-F, Schneider G.E., Massachusetts Institute of Technology, US
Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics; using nanotechnology and molecular self-assembly in biomedicine to repair injured brain structures had never been explored. To achieve axonal regeneration after injury in the CNS, [...]

An implantable Drug Delivery Device based on MEMS

Elman N.M., Ho Duc H-L, Cima M.J., Massachusetts Institute of Technology, US
An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]

Targeted Aptamer-Nanoparticles to Diminish Drug Resistance of Cancer Cells in vitro Study

Basto P., Alexis F., Levy-Nissenbaum E., Langer R., Farokzhad O., Massachusetts Institute of Technology, US
Using prostate cancer as a model, we report the drug release of pacitaxel and doxorubicin from aptamer-poly (D,L lactic co glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles used to target prostate-specific membrane antigen (PSMA), a well characterized [...]

A Nyström-Like Approach to Integral Equations with Singular Kernels

Kuo S.-H., White J.K., Massachusetts Institute of Technology, US
When boundary element methods are used to solve Laplace or Helmholtz problmes associated with complicated three-dimensional geometries, the associated integral equation is typically discretized using a piecewise constant basis, and a system of equations is [...]

Micropower Wireless Sensors

Chandrakasan A.P., Verma N., Kwong J., Daly D., Ickes N., Finchelstein D., Calhoun B., Massachusetts Institute of Technology, US
This paper describes circuit architectures and techniques to meet the specialized requirements of energy autonomous micro-sensor nodes. We address the fundamental components, namely the ADC, DSP, and radio, at the node-level to isolate important optimizations [...]

Some Novel Applications for Wireless Inertial Sensors

Paradiso J.A., Massachusetts Institute of Technology, US
Sensors have followed a corollary of Moore’s Law as they progressively decrease in size, cost, and often power. Nowhere is this more evident than with inertial sensor systems, as MEMS-based devices become steadily smaller and [...]

Microsphere templating as means of enhancing the sensitivity of thin film metal-oxide gas sensors

Rothschild A., Kim I-D, Hyodo T., Tuller H.L., Massachusetts Institute of Technology, US
Chemical and physical synthesis routes were combined to prepare macroporous thin films of semiconducting metal-oxides such as SnO2, TiO2, ZnO, and CaCu3Ti4O12 by reactive sputtering or pulsed laser deposition onto polymethylmethacrylate and polystyrene microsphere templated [...]

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