Idaho State University – Page 3

Chitosan Membrane in Combinations with Nanoparticles and Adriamycin as a Treatment to Inhibit Glioma Growth and Migration

Leung S.W., Gao W., Gu H., Bhushan A., Lai J.C.K., Idaho State University, US

Our previous and on-going studies indicated that U87 cells cultured on chitosan film/membrane exhibited significantly slower growth and proliferation kinetics compared to U87 cells cultured in the absence of chitosan film/membrane. Chitosan exhibits anti-microbial activities [...]

Biomedical Applications of Modified Carbon Glassy Electrode Sensor with Nanoparticles and Dendrimers

Leung S.W., Wang Y., Gu H., Lai J.C.K., Idaho State University, US

In our previous reports, we studied the development of biosensor platform that are capable of measuring biometabolites and environmental sensitive species, such as peroxide and nitrate/nitrate, to concentration in the order of ppb (parts per [...]

Chitosan Film/Membrane as a Surface to Alter Brain Glioma Growth and Migration

Gao W.J., Wang Y.-H., Gu H.-Y., Jandhyam S., Dukhande V.V., Lai J.C.K., Lai M.B., Leung S.W., Bhushan A., Lai J.C.K., Lai M.B., Idaho State University, US

A hydrophilic polysaccharide derived from chitin, chitosan has gained increasing popularity in biomedical applications such as tissue engineering, wound dressing, and drug delivery because of its presumed biocompatibility. These applications were founded on chemical similarities [...]

Performance Comparisons of Nanoparticle Modified Sensor Electrodes for the Detection of Nitrite and Peroxide

Lai J.C.K., Wang Y., Gao W., Gu H., Leung S.W., Idaho State University, US

For the third generation of biosensor that electrode is coupled directly with enzymes, the response time for detection is rapid but stability of the measurements and the coupled enzymes is a concern. In our research [...]

Characterization and Applications of Modified Gold Electrode Sensor with Nanoparticles

Leung S.W., Wang Y., Gu H., Lai J.C.K., Idaho State University, US

In the recent development of biosensor, response time of the sensor is drastically improved by using direct coupling of enzymes onto the surface of electrode. The drawback of the direct coupling of enzymes is denature [...]

Characterization of DNA Transport through a Semipermeable Membrane with the Effect of Surfactants

Leung S.W., Bartolin S., Daniels C.K., Lai J.C.K., Idaho State University, US

In current advances of biotechnology, various models of introduction of DNA into cells to alter their gene expression have important biomedical and bioengineering applications. However, the molecular mechanisms underlying how DNA’s cross cell and nuclear [...]

A Non-Contact Culture Model for Investigating Cell Signaling and Nanotoxicity

Gao W.J., Dukhande V.V., Jandhyam S., Wang Y.-H., Gu H.-Y., Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Leung S.W., Idaho State University, US

There is general agreement that in vitro cell model systems offer many advantages over in vivo model systems in elucidation of cell signaling and other mechanisms underlying a toxicant’s effect. While the 3-D cell models [...]

Differential Cytotoxicity of Metallic Oxide Nanoparticles in Mammalian Cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Nanomaterials have been increasingly used in industrial applications (e.g., drug delivery, additives to drugs and cosmetics). Because of their wide use, occupational exposure to nanomaterials and nanoparticles may pose as health risks. Recent studies have [...]

Silicon Dioxide Nanoparticles Exert Dissimilar Cytotoxic Effects on Mammalian Cell Types

Jandhyam S., Lai J.C.K., Lai M.B., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Applications of nanomaterials (e.g., silicon dioxide (SiO2) nanoparticles) are ubiquitous. Thus, environmental and occupational exposure to these nanoparticles could pose potential health risk. SiO2 microparticles are toxic in animals in vivo and SiO2 nanoparticles are [...]

Cytotoxic Effects of Short Multi-wall Carbon Nanotubes

Agharkar V.A., Bhushan A., Lai J.C.K., Daniels C.K., Idaho State University, US

The applications of carbon nanotubes (CNTs), a novel and important class of nanomaterials, can change paradigms of various research areas. Although biomedical applications of CNTs are increasing, their putative cytotoxicity has not been substantially addressed. [...]