Poly(caprolactone)–Pluronic– poly(caprolactone) amphiphilic copolymer nanoparticles for controlled 5-Fluorouracil delivery
5-Fluorouracil (5-FU), a pyrimidine analogue that interferes with thymidylate synthesis, has a broad spectrum of activity against solid tumors. However, 5-FU has limitations that include a short biological half-life, incomplete and non-uniform oral absorption, toxic [...]