US – Page 235 – TechConnect Briefs

Phage reporter biosensing of pathogenic agents

Ripp S., University of Tennessee, US

Considered the most abundant organism on Earth, at a population approaching 1031, bacteriophage mediate interactions with myriad bacterial hosts that has for decades been exploited in phage typing schemes for signature identification of clinical, foodborne, [...]

Fashioning of Polymer Multi-functional Nanovector Microparticle Delivery System by High Definition Microextrusion

Gabriele P.D., Hogan A., D’Ottavio J., Flemmens M., Weir M., ARmark Authentication Technologies, LLC, US

Considerable advances have recently been achieved in the development of nano-scale particles for cancer diagnostics and therapies. ARmark Authentication Technologies, LLC has developed a new technology platform to produce stable multifunctional polymeric microcarrier delivery vehicles [...]

Process Development and Industrial Manufacturing of Nanotechnology-Based Pharmaceuticals

Hassan E., Gumudavelli S., Pharmaceutics International Inc. (Pii), US

Process design and development of oral, topical and parentral nanotechnology-based pharmaceuticals are presented. Factors affecting process output and scale-up choices for various dosage forms are discussed with emphasis on critical parameter control and optimization. For [...]

Modeling of Polymer-Drug Interactions in Biodegradable Tyrosine-Based Nanospheres Using Molecular Dynamics Simulations and Docking

Costache A.D., Sheihet L., Knight D.D., Kohn J., Rutgers University, US

The intensive labor and high cost of developing new vehicles for the delivery of drugs in a controlled manner, highlights the need for a change in their discovery process. Predictive computational models can be used [...]

Imprint Lithography-Based, Multimodal Contrast Agents and the Effect of Shape and Size on Biodistribution

Herlihy K.P., Merkel T.J., DeSimone J.M., UNC Chapel Hill, US

Polymer research and modern medicine are at a critical juncture. Many state of the art, small molecule therapeutics are difficult to deliver effectively because of poor solubility and rapid elimination by the reticuloendothelial system. In [...]

In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy

Khan M.K., Nair B., Kasturirangan V., Kariapper M.S.T., Nigavekar S.S., Toth K., Rustum Y.M., El-Jawahri A., Bizimungu R., Lesniak W., Balogh L.P., Roswell Park, US

We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in [...]

Use of PBMC Partitioning to Predict RES-Uptake of a Nanoemulsion in a Colon Cancer Xenograft

Devalapally H., Clogston J.D., Amiji M.M., McNeil S., Stern S.T., SAIC-Frederick, National Cancer Institute at Frederick, US

Nanotechnology platforms have emerged as versatile carrier systems for delivery of active molecules to tumors. Nanoparticle-based formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. These carrier systems often encounter rapid [...]

Carbon Nanotubes as Molecular Nanocarriers for Antibody Delivery and Photothermal Ablation of Breast Cancer Cells

Panchapakesan B., Wickstrom E., University of Louisville, US

In this paper, the utilization of carbon nanotubes as nanocarriers for antibody delivery to IGF1R and HER2 surface receptors and selective thermal ablation of breast cancer cells is presented. IGF1R and Her2 surface receptors are [...]

PMMA/SWCNTs Composites for Prostate Brachytherapy MRI Contrast Agent Markers

Martirosyan K.S., Stafford R.J., Elliott A.M., Frank S.J., University of Houston, US

Prostate brachytherapy (PB) is an alternative to traditional external beam radiation or surgery for men who have prostate cancer. PB used implanted radioactive titanium seeds and has increased in popularity over recent years due to [...]

The development of multicolor panels with Quantum Dots-conjugated antibodies for diagnostics of Chronic Lymphoid Leukemia (CLL) by conventional flow cytometer

Barteneva N., Vorobjev I., Harvard Medical School, US

Diagnostics of leukemia and lymphomas by flow cytometry emerged in 90-th years of last century when several consensus panels had been introduced and based on three-four color cytometry. The standard flow diagnostics approach requires 10-15 [...]