Dex40-GTMAC3, modified dextran as a novel heparin antagonist

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Protamine is the only registered antidote preventing bleeding of patients treated with unfractionated heparin (UFH). However protamine may induce anaphylactic shock or serious hypotension. We aimed to develop an alternative fully synthetic UFH antidote as [...]

Nonclinical evaluation of heparin binding copolymer – HBC1 for restoring of blood coagulation after heparin treatment

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The incredible progress and wide use of various medical devices during intravascular or cardiac interventions increased the need for administration of anticoagulants, such as heparins. Protamine sulfate – a protein isolated from salmons is the [...]

The methodology and the software for the analysis of the atomic density modulation underneath the surface of a nanocrystal

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Internal structure of nanocrystals can be extracted from Pair Distribution Function, which is obtained by Fourier transform of the diffraction data. Such a transform, G(r), contains complete information on inter-atomic distances present in the investigated [...]