LB – TechConnect Briefs

Dendrigraft Poly-L-lysine (d-PLL) Coated Gold Nanoparticles in Water for siRNA Delivery to Prostate Cancer Cells

Rahme K., Minassian G., Ghanem E., Souaid E., Guo J., O’Driscoll C.M., Holmes J.D., Notre Dame University (Louaize), LB

In this study we used dendrigraft poly-L-lysine (d-PLL) as a stabilising ligand for gold nanoparticles (AuNPs) in water. The d-PLL generation two (P2) with narrow molecular weight distribution of about 7 KD was obtained by [...]

A Simple Synthesis of Polymer Coated Gold and Silver Nanoparticles in Water for Potential Use in Biomedical Applications

Rahme K., Minassian G., Ghanem E., Sarkis M., Nakhl M., El Hage R., Souaid E., Holmes J.D., Notre Dame University (Louaize), LB

Herein we describe a simple method for the synthesis of highly stable gold (Au) and silver (Ag) nanoparticles (NPs) in water. Ag and Au NPs of different surface charges (positively charged, negatively charged, or nearly [...]

Branched PEI Capped Gold Nanoparticles in Water for siRNA Delivery to Cancer Cells

Rahme K., Guo J., Biswas S., O’Driscoll C.M., Holmes J.D., Notre Dame University (Louaize), LB

Herein we describe a simple method for the synthesis of different sizes of polyethylenimine-capped gold nanoparticles (AuNPs-PEI) in water and assess their potential to deliver siRNA or other therapeutic agents to cancer cells. AuNP-PEI with [...]

Thymoquinone nanoparticle formulation and in vitro efficacy

Fakhoury I.H., Saad W.S., Gali-Muhtasib H.U., Schneider-Stock R., American University of Beirut, LB

The work summarized here pertains to the formulation of thymoquinone into controlled size nanoparticles using a recently developed solvent precipiation technique termed Flash Nanoprecipiation. Using a diblock copolymer of poly(styrene-b-ethylene oxide) as the stabilizing polymer, [...]

Hydroxylamine-O-sulfonic acid as a New Reducing Agent for the Formation of Nearly Monodisperse Gold Nanoparticles in water: Synthesis Characterisation and Bioconjugation

Rahme K., Holmes J.D., Notre Dame University (Louaize), LB

Gold nanoparticles (Au NPs), with diameters ranging between 60-150 nm, have been synthesised in water at room temperature by reducing HAuCl4.3H2O with hydroxylamine-o-sulfonic acid in the presence of sodium citrate, as stabilising agent. 15 and [...]

Highly Stable PEGylated Gold Nanoparticles in water: Applications in biology and catalysis

Rahme K., Nolan M.T., Doody T., McGlacken G.P., O’Driscoll C., Holmes J.D., Notre Dame University (NDU), LB

Gold nanoparticles (Au NPs) with diameters ranging between 5-60 nm have been synthesised in water. Functionalised polyethylene glycol-based thiol polymers (mPEG-SH) were used to stabilise the pre-synthesised Au NPs. The grafting density of different PEG [...]