Papers:
Mimicking Immune Processes by Positioning Antibodies on Surfaces — A Nanoengineering Approach
Antibody-antigen interaction is one of the most fundamental biospecific interactions. While the antibody-antigen monovalent and divalent bindings are relatively well-known in solution phase, controlling the valency on surfaces has not been attempted. Using scanning probe [...]
MembraneChipTM : Arrays of Natively Displayed Membrane Targets for Novel Drug Discovery
For the first time, naturally fluid and functional biological membranes have been integrated into a scaleable system. Previously-inaccessible membrane targets can be presented in their native environment. Domains of membrane targets naturally displayed in cell [...]
A Glucose Biosensor using Au Nanoparticle Modified Glucose Oxidase
Biosensors have a wide field of potential applications in biotechnology, process control and medicine, mainly for accurate measurement of the analyte concentration of physiological fluid to diagnose some diseases. The development of enzyme-based biosensor technology [...]
Structure-Function Relations in Self-Assembled Sphingolipids at Gas-Water Interfaces
The development in understanding cell membrane structure and function has been historically intertwined with that of the monomolecular Langmuir layer of amphiphiles at air-aqueous interfaces. Here, we present synchrotron structural studies of a variety of [...]
Biomimetic Surface Composite Effects Achieved by Interfering Laser Beams
It is observed from nature that certain insects possess the optimised surface fixing configurations against sliding and the tree body consists of different kinds of micro/nano-tissues with optimised properties to prevent breaking by wind. The [...]
Fabrication of Nanopipes using Vertically Aligned Carbon Nanofiber Templates and their Properties
Melechko A.V, McKnight T.E., Guillorn M.A., Ilic B., Merkulov V.I., Doktycz M.J., Warmac B., McCorkle D., Lowndes D.H., Simpson M.L., University of Tennessee, Knoxville, US
Fluidic structures with submicron dimensions have potential applications for sorting DNA molecules, electroanalytical sensing, and detecting and characterizing single molecule events. The fabrication of devices that function on the nanometer scale requires new approaches when [...]
Nanofiber Structures as Mimics for Cellular Membranes
Doktycz M.J., Zhang L., Melechko A.V, Klein K., McKnight T.E., Britt P.F., Guillorn M.A., Merkulov V.I., Lowndes D.H., Simpson M.L., Oak Ridge National Laboratory, US
We are investigating the use of vertically aligned carbon nanofibers (VACNFs) as a material for controlling molecular transport in a manner analogous to natural cell membranes. VACNFs can be synthesized with nanometer scale dimensions, can [...]
Electrostatic Force Microscopy Study of Open-Circuit Photovoltage from a bR/ITO Heterostructure
Bioelectronics offers a potential alternative to Si-based technology because natural evolution and selection have optimized many biological molecules to perform tasks that can only be mimicked by complicated electronic circuits. Purple membrane (PM) patches containing [...]
Dynamical Properties of Supported Membrane Junctions
We have recently introduced a supported membrane junction system. The junction consists of a conventional supported bilayer membrane, on top of which a second bilayer membrane is deposited by rupture of a giant vesicle. This [...]
Journal: TechConnect Briefs
Volume: 3, Technical Proceedings of the 2003 Nanotechnology Conference and Trade Show, Volume 3
Published: February 23, 2003
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Coatings, Surfaces & Membranes
ISBN: 0-9728422-2-5